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The Ageing Eye

Common Age-Related Eye Diseases

Featured in: PRIME magazine, Feb 22

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PRIME Magazine – Glaucoma – The Silent Thief of Sight
glaucoma-article
1 April 2024
PRIME Magazine – Glaucoma – The Silent Thief of Sight

Millions of people around the world go blind from eye diseases every year. Of the five senses, sight is probably the most important of them all…

Singapore Medical Association Newsletter – All about Eve: Your Women’s Health Questions Answered
Singapore Medical Association Newsletter – All about Eve: Your Women's Health Questions Answered
1 May 2023
Singapore Medical Association Newsletter – All about Eve: Your Women’s Health Questions Answered

Millions of people around the world go blind from eye diseases every year. Of the five senses, sight is probably the most important of them all…

The Straits Times – <br>Improving Visual Outcomes in Cataract Surgery Through Advances in Intraocular Lens Technology and Computer-Assisted Surgery
Lang Eye Centre - Cataract Screening Test
28 September 2022
The Straits Times –
Improving Visual Outcomes in Cataract Surgery Through Advances in Intraocular Lens Technology and Computer-Assisted Surgery

Millions of people around the world go blind from eye diseases every year. Of the five senses, sight is probably the most important of them all…

PRIME magazine – <br>The Ageing Eye
the-ageing-eye-tn
1 February 2022
PRIME magazine –
The Ageing Eye

Millions of people around the world go blind from eye diseases every year. Of the five senses, sight is probably the most important of them all…

PRIME magazine – <br>Window to the Soul
dr-leonard-ang-1
1 October 2020
PRIME magazine –
Window to the Soul

The eye has been termed the window to a person’s soul. It is a unique organ and is composed of many different types of tissue.

PRIME magazine – <br>An Eye Opener – Interview with Dr Leonard Ang
an-eye-opener-interview-tn
1 September 2020
PRIME magazine –
An Eye Opener – Interview with Dr Leonard Ang

A Dialogue with a Doctor Interview Series: Lang Eye Centre Medial Director Dr. Leonard Ang

PRIME magazine – <br>Understanding and Treating Glaucoma
2020-Jan-PRIME-Understanding-and-Treating-Glaucoma-1
1 January 2020
PRIME magazine –
Understanding and Treating Glaucoma

Glaucoma is the leading cause of irreversible blindness in the world, with an estimated 70 million…

Asia-Pacific Academy of Ophthalmology – <br>Cataract and IOL: Key in Achieving Spectacle Free Results
2019-APAO-Cataract-and-IOL-Key-in-Achieving-Spectacle-Free-Results-1
1 April 2019
Asia-Pacific Academy of Ophthalmology –
Cataract and IOL: Key in Achieving Spectacle Free Results

As we know, not all lenses are created equal – and certainly, not all eyes are created equal. That leaves surgeons to balance the qualities,

PRIME magazine – <br>Common Blinding Eye Diseases
common-blinding-eye-diseases-en
1 January 2019
PRIME magazine –
Common Blinding Eye Diseases

Millions of people around the world go blind from eye disease every year. Sight is so important yet, many people take it for granted until it is lost.

PRIME magazine – <br>Latest Advances In Cataract Treatment
cataract-advancement
1 September 2018
PRIME magazine –
Latest Advances In Cataract Treatment

Mdm X, a 57 year lady, noticed blurring of vision in both eyes for a few months. She saw Dr Leonard Ang, who found that her vision was poor and that she had dense cataracts in both eyes

PRIME magazine – <br>Glaucoma: The Silent Thief of Sight & New Treatments
glaucoma
1 December 2017
PRIME magazine –
Glaucoma: The Silent Thief of Sight & New Treatments

Glaucoma is the second leading cause of blindness in the world and the leading cause of irreversible blindness. It is estimated that 7 million out of 70 million glaucoma patients worldwide suffer from bilateral blindness as a result of glaucoma.

PRIME magazine – <br>Restoring Vision for Blinding Corneal Diseases
corneal-blindness
1 June 2017
PRIME magazine –
Restoring Vision for Blinding Corneal Diseases

The cornea is the central clear transparent window of the eye. Corneal blindness is one of the leading causes of treatable blindness, with more than 20 million cases happening globally

PRIME magazine – <br>Targeting Perfect Vision with the Latest Advances in Refractive Surgery
glasses
1 February 2016
PRIME magazine –
Targeting Perfect Vision with the Latest Advances in Refractive Surgery

Refractive errors, such as myopia and presbyopia (lao hua), are common causes of poor vision. Advances in refractive surgery enable all forms of refractive error to be corrected, and patients can achieve excellent vision with greater precision and safety, without the need for spectacles

PRIME magazine – <br>Advances in Retinal Disease Treatment
eye-side
1 January 2016
PRIME magazine –
Advances in Retinal Disease Treatment

Retinal diseases such as age-related macular degeneration and diabetic retinopathy are 2 leading causes of blindness.

Medical Grapevine – <br>Modern Methods of Correcting Refractive Errors
technology
24 November 2015
Medical Grapevine –
Modern Methods of Correcting Refractive Errors

Myopia is also known as shortsightedness. This usually occurs when the eyeball is longer and light rays are focused in front of the retina.

Television

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Selected Scientific Publications

1. Reza HM, Ng BY, Phan TT, Tan DT, Beuerman RW, Ang LP. Characterization of a Novel Umbilical Cord Lining Cell with CD227 Positivity and Unique Pattern of
P63 Expression and Function. Stem Cell Reviews and Reports 2011 Sep;7(3):624-38

2. Ang LPK, Reza HM, Tan XW, Do TP, Thein ZM, Yap C, Tan HK, Tan DTH, Beuerman RW. The Ex Vivo Expansion Of Conjunctival And Limbal Epithelial Cells Using
Cord Blood Serum-Supplemented Culture Medium. Invest. Ophthalmol. Vis. Sci 2011 Aug 3;52(9):6138-47.

3. Reza HM, Ng BY, Gimeno FL, Phan TT, Ang LP. Development of a bioengineered cell sheet from cord lining stem cells for cornea regeneration in limbal stem
cell deficient rabbit eyes. Stem Cell Reviews and Reports 2011. 2011 Mar 10.

4. Ang LP, Reza HM, Ng BY, Phan TT, Tan DT, Beuerman RW. Isolation and Characterization of a Novel Stem Cell Population from Human Umbilical Cord. Catalyst May 2011.

5. Ang LPK, Tanioka H, Ang LPS, Do TP, Kawasaki S, Yamasaki K, Koizumi N, Nakamura T, Yokoi N, Komuro A, Inatomi T, Kinoshita S.The Use of Cultivated Human
Conjunctival Epithelial Transplantation for Total Limbal Stem Cell Deficiency. Invest. Ophthalmol. Vis. Sci. 2010 51: 758-764.

6. Ang LP, Reza HM, Ng BY, Phan TT, Tan DT, Beuerman RW. Isolation and Characterization of a Novel Stem Cell Population from Human Umbilical Cord. Ann Acad Med Nov 2010;11s:S4.

7. Lim LS, How AC, Ang LP, Tan DT. Gundersen flaps in the management of ocular surface disease in an Asian population. Cornea. 2009 Aug;28(7):747-51.

8. Tong L, Chew J, Yang H, Ang LP, Tan DT, Beuerman RW. Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological
phenomenon using genome wide expression data. BMC Med Genomics. 2009 Mar 10;2:14.

9. Zhou L, Beuerman RW, Ang LP, Chan CM, Li SF, Chew FT, Tan DT. Elevation of human alpha-defensins and S100 calcium-binding proteins A8 and A9 in tear
fluid of patients with pterygium. Invest Ophthalmol Vis Sci. 2009 May;50(5):2077-86.

10. Ang LPK, Reza HM, Tan XW, Do TP, Thein ZM, Yap C, Tan HK, Tan DTH, Beuerman RW. The novel use of a cord blood serum-supplemented culture medium for the ex
vivo expansion of conjunctival and limbal epithelial cells. Ann Acad Med Oct 2010;10s:S1.

11. Ang LP, Sayegh RR, Foster SC, Dohlman CH. The Boston Keratoprosthesis in Stevens-Johnson Syndrome. American Journal of Ophthalmology 2008
Mar;145(3):438-44. Epub 2008.

12. Ang LPS, Ang LP. Current Understanding of the Treatment and Outcome of Acute Primary Angle-Closure Glaucoma: An Asian Perspective. Ann Acad Med Singapore. 2008 Mar;37(3):210-215.

13. Ang LPK, Lim LS, Do TP, Thein Z, Cajucom-Uy H, R Beurman, Tan DTH. Transplantation of a Bioengineered Serum-Free Derived Conjunctival Epithelial
Equivalent for the Treatment of Severe Corneal and Ocular Surface Disease. Ann Acad Med Singapore Nov 2008; 11s: S2

14. Tan DT, Janardhanan P, Zhou H, Chan YH, Htoon HM, Ang LP, Lim LS. Penetrating Keratoplasty in Asian Eyes The Singapore Corneal Transplant Study.
Ophthalmology. 2007 Nov 29; [Epub ahead of print]

15. Ang LP, Chua JL, Tan DT. Current concepts and techniques in pterygium treatment. Curr Opin Ophthalmol. 2007 Jul;18(4):308-13.

16. Ang LP, Higashihara H, Sotozono C, Shanmuganathan VA, Dua H, Tan DT, Kinoshita S. Argon laser iridotomy-induced bullous keratopathy- a growing problem
in Japan. Br J Ophthalmol. 2007 Jun 13; [Epub ahead of print]

17. Ang LP, Lee MW, Seah LL, Cheong P, Rootman J. Orbital cellulitis following intralesional corticosteroid injection for periocular capillary haemangioma. Eye. 2007 Jul;21(7):999-1001.

18. Sotozono C, Ang LP, Koizumi N, Higashihara H, Ueta M, Inatomi T, Yokoi N, Kaido M, Dogru M, Shimazaki J, Tsubota K, Yamada M, Kinoshita S.
New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome. Ophthalmology 2007
Jul;114(7):1294-302

19. Ghanem RC, de la Cruz J, Tobaigy FM, Ang LP, Azar DT.
LASIK in the presbyopic age group: safety, efficacy, and predictability in 40- to 69-year-old patients. Ophthalmology 2007 Jul;114(7):1303-10.

20. Ang LPK, Nakamura T, Inatomi T, Sotozono C, Koizumi N, Kinoshita S. Autologous serum-derived cultivated oral epithelial transplantation for severe
ocular surface disease. Archives of Ophthalmology 2006;124:1543-1551.

21. Ang LPK, Sotozono C, Koizumi N, Suzuki T, Inatomi T, Kinoshita S. A comparison between cultivated and conventional limbal stem cell transplantation for
Stevens-Johnson syndrome. American Journal of Ophthalmology 2007;143(1):178-80.

22. Tanioka H, Kawasaki S, Yamasaki K, Ang LPK, Yokoi N, Komuro A, Inatomi T, Kinoshita S. Establishment of a cultivated human conjunctival epithelium as
an alternative tissue source for autologous corneal epithelial transplantation. Invest Ophthalmol Vis Sci. 2006 Sep ;47:3820-7.

23. Tan CSH, Ang LPK, Choo CT, Cheah EST, Chee SP. Epithelium-lined orbital cysts – a late complication of silicone implants. Ophthalmic plastic and reconstructive surgery 2006;22:398-400.

24. Nakamura T, Inatomi T, Sotozono C, Ang LP, Koizumi N, Yokoi N, Kinoshita S. Transplantation of Autologous Serum-Derived Cultivated Corneal Epithelial Equivalents for the Treatment of Severe Ocular Surface Disease. Ophthalmology. 2006 Aug 11; [Epub ahead of print]

25. Nakamura T, Ang LPK, Rigby H, Sekiyama E, Inatomi T, Sotozono C, Fullwood NJ, Kinoshita S. The use of autologous serum in the development of corneal
and oral epithelial equivalents in patients with Stevens Johnson syndrome. Invest Ophthalmol Vis Sci. 2006 Mar;47(3):909-16.

26. Nakamura T, Inatomi T, Sekiyama E, Ang LPK, Yokoi N, Kinoshita S. Novel clinical application of sterilized, freeze-dried amniotic membrane to treat patients with pterygium. Acta Ophthalmol Scand. 2006 Jun;84(3):401-5.

27. Lim LS, Ho CL, Ang LP, Aung T, Tan DT. Inferior corneal decompensation following laser peripheral iridotomy in the superior iris. American Journal of Ophthalmology 2006 Jul;142(1):166-8.

28. Friedman DS, Chew PT, Gazzard G, Ang LP, Lai YF, Quigley HA, Seah SK, Aung T. Long-term outcomes in fellow eyes after acute primary angle closure in the contralateral eye. Ophthalmology. 2006 Jul;113(7):1087-91.

29. Ang LPK. Advances in cornea and ocular surface transplantation. SingVision Dec 2006.

30. Ang LPK, Cheng ZY, Beuerman RW, Teoh SH, Zhu X, Tan DTH. The development of a serum-free derived bioengineered conjunctival epithelial equivalent using
an ultra-thin poly(e-caprolactone) membrane substrate. Investigative Ophthalmology and Visual Science 2006;47(1):105-12.

31. Zhu X, Beuerman RW, Chan-Park MBE, Cheng ZY, Ang LPK, Tan DTH. Enhancement of the Mechanical and Biological Properties of a Biomembrane for Tissue
Engineering the Ocular Surface. Annals Academy of Medicine 2006 Mar;35(3):210-5.

32. Al-Tobaigy FM, Ang LPK, Ghanem RC, Azar DT. Efficacy, predictability, and safety of epi-lasik for the correction of myopia. Manuscript under review.

33. Ang LP. Cornea and ocular surface disease treatment, stem cell transplantation, and refractive surgery. SNEC CME Jun 2006.

34. Zhou L, Beuerman RW, Foo YH, Liu SP, Ang LPK, Tan DTH. Characterisation of human tear proteins using high-resolution mass spectrometry. Annals Academy of Medicine Singapore. 2006 Jun; 35:400-7.

35. Ang LPK, Tan DTH, Cajucom-Uy H, Phan TT, R Beurman, R Lavker. Autologous Cultivated Conjunctival Transplantation for Pterygium Surgery. American Journal of Ophthalmology 2005;139(4):611-619.

36. Ang LPK, Tan DTH, Seah CJY, Beuerman RW. The Use Of Human Serum In Supporting The In Vitro And In Vivo Proliferation Of Human
Conjunctival Epithelial Cells. British Journal of Ophthalmology 2005; 89:748-752.

37. Ang LPK, Tan DTH. Autologous cultivated conjunctival transplantation for extensive recurrent viral papillomata. American Journal of Ophthalmology 2005; 140:136-138.

38. Ang LPK, Tan DTH, Phan TT, Beuerman RW, RM Lavker. The In Vitro And In Vivo Proliferative Capacity Of Serum-Free Cultivated Human
Conjunctival Epithelial Cells. Current Eye Research 2004;28(5):307-317.

39. Ang LPK, Tan DTH, Beuerman RW, Phan TT, RM Lavker. The Development Of A Conjunctival Epithelial Equivalent With Improved Proliferative Properties Using
A Multistep Serum-Free Culture System. Investigative Ophthalmology and Visual Science 2004;45(6):1789-1795.

40. Tan DTH, Ang LPK, Beuerman RW. Reconstruction of the Ocular Surface by Transplantation of a Serum-free Derived Cultivated Conjunctival Epithelial
Equivalent. Transplantation 2004;77(11):1729-1734.

41. Tan DTH, Ang LPK. Automated Lamellar Therapeutic Keratoplasty For Post-PRK Corneal Scarring And Thinning. American Journal of Ophthalmology
2004;138(6):1067-9.

42. Tan DTH, Ang LPK. Modified Automated Lamellar Therapeutic Keratoplasty For Keratoconus – A New Technique. Cornea 2006;25(10):1217-9.

43. Zhou L, Huang LQ, Beuerman RWW, Grigg M, Li SFY, Chew FT, Ang LPK, Stern ME, Tan D. Proteomic Analysis of Human Tears: Defensin Expression after Ocular
Surface Surgery. Journal of Proteome Research 2004, 3(3): 410-416.

44. Ang LPK, Aung T, Chua WH, Chew PTK. Visual Field Loss From Primary Angle-Closure Glaucoma In An Asian Population: A Comparative Study Of Symptomatic
And Asymptomatic Disease Presentation. Ophthalmology 2004; 111: 1636-40.

45. Ang LPK, Tan DTH, Beuerman RW, RM Lavker. Ocular surface epithelial stem cells: Implications for ocular surface homeostasis, in Pfulgfelder S, Beuerman
RW, Stern ME (eds). Dry Eye and Ocular Surface Disorders. Marcel Dekker 2004. P225-46.

46. Ang LPK, Tan DTH, Cajucon-Uy H, Phan TT, R Beurman, R Lavker. Reconstruction of the Ocular Surface by Transplantation of a Serum-free Derived
Cultivated Conjunctival Epithelial Equivalent. Annals Academy of Medicine 2004;33:S55-56.

47. Ang LPK, Tan DTH. Ocular Surface Stem Cells And Disease: Current Concepts And Clinical Applications. Annals Academy of Medicine 2004;33(5):576-80.

48. Ang LPK, Cheng ZY, Teoh SH, Zhu X, Beuerman RW, Tan DTH. The development of a transplantable bioengineered conjunctival equivalent using an ultra-thin
polycaprolactone membrane substrate. American Journal of Ophthalmology 2005;139:s36-7.

49. Ang LPK, Tan DTH, Beuerman RW, Phan TT, RM Lavker. The development of a serum-free derived conjunctival equivalent with improved proliferative
properties for clinical transplantation. American Journal of Ophthalmology 2005;139:s36.

50. Zhu X, Beuerman RW, Chan-Park MBE, Ang LPK, Tan DTH. Fabrication of a novel gelatine-chitosan substrate for tissue engineering of rabbit conjunctival
epithelial equivalent. American Journal of Ophthalmology 2005;139:s43.

51. Ang LPK, Tan DTH, Cajucom-Uy H, Phan TT, R Lavker, R Beurman. The use of an autologous serum-free cultivated conjunctival tissue-equivalent in the
surgical management of ocular surface diseases. American Journal of Ophthalmology 2005;139:s10.

52. Ang LPK, Tan DTH. Stem cells of the eye, in Stem Cells: From Bench To Bedside. In press.

53. Aung T, Friedman DS, Chew PTK, Ang LPK, Gazzard G, Lai YF, Yip L, H Lai, Quigley H, Seah SKL. Long-term outcomes in Asians after acute primary
angle-closure. Ophthalmology 2004;111:1464-9.

54. Ang LPK, Yap EY, Fam HB. Ophthalmic Artery and Central Retinal Vein Occlusion in Primary Antiphospholipid Syndrome. Eye 2004;18(4):439-440.

55. Ang LPK, Tan DTH, Beuerman RW, Phan TT, RM Lavker. Development Of An Autologous Serum-Free Cultivated Conjunctival Equivalent For Clinical
Transplantation – A New Treatment Modality For Ocular Surface Diseases. SGH Proceedings 2003;12(3):161-169.

56. Ang LPK, Phan TT, Tan DTH, Beuerman RW, Lavker RM. Serum-Free Cultivation Of Human Conjunctival Epithelial Cells – The Development Of A New Culture
Method For Ocular Surface Epithelial Cells. SGH Proceedings 2003;12(3S):S76.

57. SE Ti, Ang LPK, Tan DTH. Ocular surface disease, in Clinical Ophthalmology: an Asian perspective. In press.

58. Ang LPK, Abano J, Li L, Tan DTH. Corneal transplantation in Asian eyes, in Clinical Ophthalmology: an Asian perspective. In press.

59. Ang LPK, Tan DTH. Stem Cells Of The Eye – An Illuminating Viewpoint. Singapore Medical Association News 2003;35(6):8-9.

60. M Rosman, Aung T, Ang LPK, Chew PTK, J M Liebmann, R Ritch. Chronic Angle-closure with Glaucomatous Damage: Long-term Clinical Course in a North
American Population and Comparison with an Asian Population. Ophthalmology 2002;109(12)

61. Aung T, Z Alsagoff, Ang LPK, Chew PTK. Angle-Closure Glaucoma. Ophthalmology 2002;109:1-2.

62. Tan, DT; Ang LPK; Theng, JTS; Gomezperalta, C; Cajucom-Uy, H; Beuerman, RW; Lavker, RM.

Transplantation of autologous cultured conjunctiva for pterygium surgery
. Investigative Ophthalmology & Visual Science 2002;43:s121.

63. Ang LPK, Aung T, Chew PTK. Acute Primary Angle-Closure Glaucoma: Long-term Intraocular Pressure Outcome in an Asian Population. American Journal of Ophthalmology 2001;1:7-12

64. Ang LPK. Ocular Surface Stem Cells – Current Concepts and Implications

Asia Pacific Biotech
2002;6(2):55

65. Ang LPK, Aung T, Chew PTK. Acute primary angle closure in an asian population: Long-term outcome of the fellow eye after prophylactic laser peripheral
iridotomy. Ophthalmolgy 2000;107(11):2092-6

66. Z Alsagoff, Aung T, Ang LPK, Chew PTK. Long-term Clinical Course of Primary Angle-Closure Glaucoma in an Asian Population. Ophthalmology
2000;107:2300-4

67. Ang LPK, H M Lee, Au Eong KG, Lim ATH, Yap EY. Endogenous Klebsiella Endophthalmitis. Eye 2000;14(6):855-8

68. Ang LPK, Yap EY, Fam HB. Bilateral Choroidal Infarction in Antiphospholipid Syndrome. Clinical and Experimental Ophthalmology 2000; 28(4):
326-8

69. Ang LPK, Heng WJ, W K Chan. Episcleral Neurofibroma. International Ophthalmology 1999;20:207-10

70. Ang LPK, Sim DHJ, Chiang GSC, V S H Yong. Iris Varix. Eye 1997;11(5):733-5

71. Ang LPK, Au Eong KG, S G Ong. Herpes Zoster Ophthalmicus. Journal Of Pediatric Ophthalmology & Strabismus 2001;38(3):174-6

SELECTED BOOK CHAPTERS

72. Ang LPK, Tan DTH, Beuerman RW, RM Lavker. Ocular surface epithelial stem cells: Implications for ocular surface homeostasis, in Pfulgfelder S, Beuerman

RW, Stern ME (Eds). Dry Eye and Ocular Surface Disorders. Marcel Dekker 2004. P225-46.

73. Ang LPK, Tan DTH. Stem cells of the eye, in Bongso A., Lee EH (Eds). Stem Cells: From Bench To Bedside. World Scientific
2005.

74. Ang LPK, Abano J, Li L, Tan DTH. Corneal transplantation in Asian eyes, in Ang CL, Chee SP, Jap AH, Tan DT, Wong TY (Eds). Clinical Ophthalmology: an Asian perspective. Elsevier 2005. P253-266.

75. SE Ti, Ang LPK, Tan DTH. Ocular surface disease, in Ang CL, Chee SP, Jap AH, Tan DT, Wong TY (Eds). Clinical Ophthalmology: an Asian perspective. Elsevier 2005. P223-234.

76. Ang LPK, Azar DT. LASEK and EpiLASIK. In: Yanoff M, Duker J (Eds). Ophthalmology, 4th Edition. Elsevier. 2012.

77. Ang LPK, Azar DT. Penetrating Keratoplasty. In: Albert DM, Jakobiec FA (Eds). Principles and Practice of Ophthalmology, 3rd Edition
Elsevier. 2007

78. Ang LPK, Azar DT. Ocular surface stem cells and wound healing response to injury and infection. In: Albert DM, Jakobiec FA (Eds). Principles and Practice of Ophthalmology, 3rd Edition Elsevier. 2007